Journal article
IL-23 in arthritic and inflammatory pain development in mice
KMC Lee, Z Zhang, A Achuthan, AJ Fleetwood, JE Smith, JA Hamilton, AD Cook
Arthritis Research and Therapy | BMC | Published : 2020
Open access
Abstract
Background: The cytokine, interleukin-23 (IL-23), can be critical for the progression of inflammatory diseases, including arthritis, and is often associated with T lymphocyte biology. We previously showed that certain lymphocyte-independent, inflammatory arthritis and pain models have a similar requirement for tumour necrosis factor (TNF), granulocyte macrophage-colony stimulating factor (GM-CSF), and C-C motif ligand 17 (CCL17). Given this correlation in cytokine requirements, we explored whether IL-23 might interact with this cytokine cluster in the control of arthritic and inflammatory pain. Methods: The role of IL-23 in the development of pain-like behaviour was investigated using mouse ..
View full abstractGrants
Funding Acknowledgements
A.D. Cook and J.A. Hamilton were supported by a grant (1085240), and J.A. Hamilton by a Senior Principal Research Fellowship from the National Health and Medical Research Council of Australia (NHMRC). A.D. Cook and J.A. Hamilton were supported in part by funding from GSK.